Tetrahydroberberine, a pharmacologically active naturally occurring alkaloid.

Role of psilocybin in the treatment of depression.

Psilocybin is a naturally occurring alkaloid, pharmacologically similar to the classic hallucinogen lysergic acid diethylamide (LSD). Although primarily used as a recreational drug or an entheogen in particular cultural settings, recent population based studies have shown that it does not lead to serious physical or mental health problems or dependent use. In view of recent work demonstrating p...

Pronuciferine N-oxide, a proaporphine N-oxide alkaloid from Berberis coletioides.

Pronuciferine N-oxide (1), a proaporphine N-methyl-N-oxide alkaloid, along with the parent alkaloid pronuciferine (2) were isolated from Berberis coletioides. The structure of the new compound was determined by spectroscopic evidence. Compound 1 is the first naturally occurring proaporphinoid alkaloid with an N-oxide functionality.

Bacterial Expression and Functional Characterization of A Naturally Occurring Exon6-less Preprochymosin cDNA

Chymosin (Rennin EC 3.4.23.4), an aspartyl proteinase, is the major proteolytic enzyme in the fourthstomach of the unweaned calf, and it is formed by proteolytic activation of its zymogene, prochymosin.Following the cloning of synthesized cDNAs on mRNA pools extracted from the mucosa of the calf fourthstomach, we have identified an alternatively spliced form of preprochymosin ...

The role of the tropane skeleton in drug research

This review describes certain reminiscences about an area of chemical pharmacology I have been involved with, on and off, for many years. Specifically it focuses on tropane, a fascinating, naturally occurring bicyclic chemical ring system that lends itself to many pharmaceutical and therapeutic applications. My involvement with the tropane ring has started more than 60 years ago in 1949, when, ...

Coinfection Associated with Naturally Occurring Cryptosporidiosis in Broilers